Metabolism of daidzein by Nocardia species NRRL 5646 and Mortierella isabellina ATCC 38063

The phytoestrogen daidzein was metabolized by Nocardia species NRRL 5646 to give two metabolites obtained by hydroxylation and methylation. These metabolites were spectrally characterized as 7-methoxy-4′-hydroxyisoflavone (isoformononetin) and 7,8-dimethoxy-4′-hydroxyisoflavone. Mortierella isabelli...

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Veröffentlicht in:	Phytochemistry (Oxford) 2005-05, Vol.66 (9), p.1007-1011
Hauptverfasser:	Maatooq, Galal T., Rosazza, John P.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal and plant ecology Animal, plant and microbial ecology Autoecology biochemical pathways Biological and medical sciences Biotransformation Chemical constitution chemical structure Daidzein daidzein-4'-rhamnopyranoside Fundamental and applied biological sciences. Psychology Hydroxylation Isoflavone Isoflavones - metabolism Isoformononetin metabolites Methylation Microbial metabolism Models, Chemical Molecular Structure Morteirella isabellina Mortierella Mortierella - metabolism Mortierella isabellina Nocardia Nocardia - metabolism Nocardia species Phytoestrogens - metabolism Plant physiology and development Plants and fungi spectral analysis
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Zusammenfassung:	The phytoestrogen daidzein was metabolized by Nocardia species NRRL 5646 to give two metabolites obtained by hydroxylation and methylation. These metabolites were spectrally characterized as 7-methoxy-4′-hydroxyisoflavone (isoformononetin) and 7,8-dimethoxy-4′-hydroxyisoflavone. Mortierella isabellina ATCC 38063 was able to metabolize daidzein to the unusual metabolite daidzein-4′-rhamnopyranoside The phytoestrogen daidzein was metabolized by Nocardia species NRRL 5646 to give two metabolites obtained by hydroxylation and methylation. These metabolites were spectrally characterized as 7-methoxy-4′-hydroxyisoflavone (isoformononetin) and 7,8-dimethoxy-4′-hydroxyisoflavone. Mortierella isabellina ATCC 38063 was able to metabolize daidzein to the unusual metabolite daidzein-4′-rhamnopyranoside.
ISSN:	0031-9422 1873-3700
DOI:	10.1016/j.phytochem.2005.03.013