Posaconazole as Salvage Therapy in Patients with Chronic Granulomatous Disease and Invasive Filamentous Fungal Infection

Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment wi...

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Veröffentlicht in:	Clinical infectious diseases 2005-06, Vol.40 (11), p.1684-1688
Hauptverfasser:	Segal, Brahm H., Barnhart, Lisa A., Anderson, Victoria L., Walsh, Thomas J., Malech, Harry L., Holland, Steven M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - therapeutic use Antifungals Aspergillosis Biological and medical sciences Biopsies Brief Reports Child Chronic granulomatous disease Chronic illnesses Female Fungal infections Fungi Fungi - isolation & purification Fungi - pathogenicity Granulomatous Disease, Chronic - complications Hematologic and hematopoietic diseases Humans Infections Infectious diseases Lung Diseases, Fungal - complications Lung Diseases, Fungal - drug therapy Lung Diseases, Fungal - genetics Lung Diseases, Fungal - microbiology Lungs Male Medical sciences Medical treatment Other diseases. Hematologic involvement in other diseases Patients Pharmacology. Drug treatments Pneumonia Salvage Therapy Therapy Triazoles - therapeutic use
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Beschreibung
Zusammenfassung:	Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/430068