Serotonin-type 3 receptors mediate intestinal Polycose- and glucose-induced suppression of intake

Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania Submitted 3 November 2004 ; accepted in final form 13 February 2005 Ondansetron, a selective serotonin-type 3 (5-HT 3 ) receptor antagonist, was used to test the hypothesis that duodenal infusion of isosmotic solutions of Polycose or its hydrolytic product glucose suppressed intake through 5-HT 3 receptors. Polycose suppressed sucrose intake across both concentrations infused (132 mM, 7.6 ± 0.6 ml; 263 mM, 2.3 ± 0.5 ml), compared with intake under control conditions (12.6 ± 0.3 ml, P