N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake
A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2006-05, Vol.16 (10), p.2714-2718 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Boot, J.R. Boulet, S.L. Clark, B.P. Cases-Thomas, M.J. Delhaye, L. Diker, K. Fairhurst, J. Findlay, J. Gallagher, P.T. Gilmore, J. Harris, J.R. Masters, J.J. Mitchell, S.N. Naik, M. Simmonds, R.G. Smith, S.M. Richards, S.J. Timms, G.H. Whatton, M.A. Wolfe, C.N. Wood, V.A. |
| description | A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. |
| doi_str_mv | 10.1016/j.bmcl.2006.02.008 |
| format | Article |
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A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2006.02.008</identifier><identifier>PMID: 16497500</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aminopiperidines ; Biological and medical sciences ; Inhibitors ; Medical sciences ; Miscellaneous ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Norepinephrine ; Norepinephrine - antagonists & inhibitors ; Pharmacology. Drug treatments ; Piperidines - chemistry ; Piperidines - pharmacology ; Reuptake ; Serotonin ; Serotonin Uptake Inhibitors - chemistry ; Serotonin Uptake Inhibitors - pharmacology ; Structure-Activity Relationship ; Transporter</subject><ispartof>Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2714-2718</ispartof><rights>2006 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-53e9f0b57382bdf5c440f43acc9f13606da9cf5cfd6d9c4550da0c93be61a9b63</citedby><cites>FETCH-LOGICAL-c415t-53e9f0b57382bdf5c440f43acc9f13606da9cf5cfd6d9c4550da0c93be61a9b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X06001806$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17642453$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16497500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boot, J.R.</creatorcontrib><creatorcontrib>Boulet, S.L.</creatorcontrib><creatorcontrib>Clark, B.P.</creatorcontrib><creatorcontrib>Cases-Thomas, M.J.</creatorcontrib><creatorcontrib>Delhaye, L.</creatorcontrib><creatorcontrib>Diker, K.</creatorcontrib><creatorcontrib>Fairhurst, J.</creatorcontrib><creatorcontrib>Findlay, J.</creatorcontrib><creatorcontrib>Gallagher, P.T.</creatorcontrib><creatorcontrib>Gilmore, J.</creatorcontrib><creatorcontrib>Harris, J.R.</creatorcontrib><creatorcontrib>Masters, J.J.</creatorcontrib><creatorcontrib>Mitchell, S.N.</creatorcontrib><creatorcontrib>Naik, M.</creatorcontrib><creatorcontrib>Simmonds, R.G.</creatorcontrib><creatorcontrib>Smith, S.M.</creatorcontrib><creatorcontrib>Richards, S.J.</creatorcontrib><creatorcontrib>Timms, G.H.</creatorcontrib><creatorcontrib>Whatton, M.A.</creatorcontrib><creatorcontrib>Wolfe, C.N.</creatorcontrib><creatorcontrib>Wood, V.A.</creatorcontrib><title>N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.</description><subject>Aminopiperidines</subject><subject>Biological and medical sciences</subject><subject>Inhibitors</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Norepinephrine</subject><subject>Norepinephrine - antagonists & inhibitors</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperidines - chemistry</subject><subject>Piperidines - pharmacology</subject><subject>Reuptake</subject><subject>Serotonin</subject><subject>Serotonin Uptake Inhibitors - chemistry</subject><subject>Serotonin Uptake Inhibitors - pharmacology</subject><subject>Structure-Activity Relationship</subject><subject>Transporter</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxRtR3HH1C3iQvri3jJXuJN0RL8viP1jGi4K3kE4qTGbTnTbpXphvb4YZ2JteqqD4vUfxXlW9pbClQMWHw3YYTdg2AGILzRagf1ZtKBOMtAz482oDUgDpJft9Vb3K-QBAGTD2srqigsmOA2wqtyO34eEYyI7odAwjLvtjmP2MyVs_EUb06CfMH-tdfMRQ21WH2k97P_glplxHV2dMcYmTn2o92XqKCeeimPepzDrhOi_6AV9XL5wOGd9c9nX168vnn3ffyP2Pr9_vbu-JYZQvhLcoHQy8a_tmsI4bxsCxVhsjHW0FCKulKWdnhZWGcQ5Wg5HtgIJqOYj2uro5-84p_lkxL2r02WAIesK4ZiW6nnLBuv-CtKOc950sYHMGTYo5J3RqTn4sWSkK6lSDOqhTDepUg4JGlRqK6N3FfR1GtE-SS-4FeH8BdDY6uKQn4_MT1wnWMN4W7tOZwxLao8eksvE4GbQ-oVmUjf5ff_wFv0WnuQ</recordid><startdate>20060515</startdate><enddate>20060515</enddate><creator>Boot, J.R.</creator><creator>Boulet, S.L.</creator><creator>Clark, B.P.</creator><creator>Cases-Thomas, M.J.</creator><creator>Delhaye, L.</creator><creator>Diker, K.</creator><creator>Fairhurst, J.</creator><creator>Findlay, J.</creator><creator>Gallagher, P.T.</creator><creator>Gilmore, J.</creator><creator>Harris, J.R.</creator><creator>Masters, J.J.</creator><creator>Mitchell, S.N.</creator><creator>Naik, M.</creator><creator>Simmonds, R.G.</creator><creator>Smith, S.M.</creator><creator>Richards, S.J.</creator><creator>Timms, G.H.</creator><creator>Whatton, M.A.</creator><creator>Wolfe, C.N.</creator><creator>Wood, V.A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060515</creationdate><title>N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake</title><author>Boot, J.R. ; Boulet, S.L. ; Clark, B.P. ; Cases-Thomas, M.J. ; Delhaye, L. ; Diker, K. ; Fairhurst, J. ; Findlay, J. ; Gallagher, P.T. ; Gilmore, J. ; Harris, J.R. ; Masters, J.J. ; Mitchell, S.N. ; Naik, M. ; Simmonds, R.G. ; Smith, S.M. ; Richards, S.J. ; Timms, G.H. ; Whatton, M.A. ; Wolfe, C.N. ; Wood, V.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-53e9f0b57382bdf5c440f43acc9f13606da9cf5cfd6d9c4550da0c93be61a9b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aminopiperidines</topic><topic>Biological and medical sciences</topic><topic>Inhibitors</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Norepinephrine</topic><topic>Norepinephrine - antagonists & inhibitors</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperidines - chemistry</topic><topic>Piperidines - pharmacology</topic><topic>Reuptake</topic><topic>Serotonin</topic><topic>Serotonin Uptake Inhibitors - chemistry</topic><topic>Serotonin Uptake Inhibitors - pharmacology</topic><topic>Structure-Activity Relationship</topic><topic>Transporter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boot, J.R.</creatorcontrib><creatorcontrib>Boulet, S.L.</creatorcontrib><creatorcontrib>Clark, B.P.</creatorcontrib><creatorcontrib>Cases-Thomas, M.J.</creatorcontrib><creatorcontrib>Delhaye, L.</creatorcontrib><creatorcontrib>Diker, K.</creatorcontrib><creatorcontrib>Fairhurst, J.</creatorcontrib><creatorcontrib>Findlay, J.</creatorcontrib><creatorcontrib>Gallagher, P.T.</creatorcontrib><creatorcontrib>Gilmore, J.</creatorcontrib><creatorcontrib>Harris, J.R.</creatorcontrib><creatorcontrib>Masters, J.J.</creatorcontrib><creatorcontrib>Mitchell, S.N.</creatorcontrib><creatorcontrib>Naik, M.</creatorcontrib><creatorcontrib>Simmonds, R.G.</creatorcontrib><creatorcontrib>Smith, S.M.</creatorcontrib><creatorcontrib>Richards, S.J.</creatorcontrib><creatorcontrib>Timms, G.H.</creatorcontrib><creatorcontrib>Whatton, M.A.</creatorcontrib><creatorcontrib>Wolfe, C.N.</creatorcontrib><creatorcontrib>Wood, V.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boot, J.R.</au><au>Boulet, S.L.</au><au>Clark, B.P.</au><au>Cases-Thomas, M.J.</au><au>Delhaye, L.</au><au>Diker, K.</au><au>Fairhurst, J.</au><au>Findlay, J.</au><au>Gallagher, P.T.</au><au>Gilmore, J.</au><au>Harris, J.R.</au><au>Masters, J.J.</au><au>Mitchell, S.N.</au><au>Naik, M.</au><au>Simmonds, R.G.</au><au>Smith, S.M.</au><au>Richards, S.J.</au><au>Timms, G.H.</au><au>Whatton, M.A.</au><au>Wolfe, C.N.</au><au>Wood, V.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2006-05-15</date><risdate>2006</risdate><volume>16</volume><issue>10</issue><spage>2714</spage><epage>2718</epage><pages>2714-2718</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16497500</pmid><doi>10.1016/j.bmcl.2006.02.008</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2714-2718 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aminopiperidines Biological and medical sciences Inhibitors Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Norepinephrine Norepinephrine - antagonists & inhibitors Pharmacology. Drug treatments Piperidines - chemistry Piperidines - pharmacology Reuptake Serotonin Serotonin Uptake Inhibitors - chemistry Serotonin Uptake Inhibitors - pharmacology Structure-Activity Relationship Transporter |
| title | N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake |
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