N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake

A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-05, Vol.16 (10), p.2714-2718
Hauptverfasser:	Boot, J.R., Boulet, S.L., Clark, B.P., Cases-Thomas, M.J., Delhaye, L., Diker, K., Fairhurst, J., Findlay, J., Gallagher, P.T., Gilmore, J., Harris, J.R., Masters, J.J., Mitchell, S.N., Naik, M., Simmonds, R.G., Smith, S.M., Richards, S.J., Timms, G.H., Whatton, M.A., Wolfe, C.N., Wood, V.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopiperidines Biological and medical sciences Inhibitors Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Norepinephrine Norepinephrine - antagonists & inhibitors Pharmacology. Drug treatments Piperidines - chemistry Piperidines - pharmacology Reuptake Serotonin Serotonin Uptake Inhibitors - chemistry Serotonin Uptake Inhibitors - pharmacology Structure-Activity Relationship Transporter
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Zusammenfassung:	A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.02.008