Preeclampsia: A renal perspective

Preeclampsia: A renal perspective. Preeclampsia is a syndrome that affects 5% of all pregnancies, producing substantial maternal and perinatal morbidity and mortality. The aim of this review is to summarize our current understanding of the pathogenesis of preeclampsia with special emphasis on the re...

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Veröffentlicht in:	Kidney international 2005-06, Vol.67 (6), p.2101-2113
Hauptverfasser:	Karumanchi, S. Ananth, Maynard, Sharon E., Stillman, Isaac E., Epstein, Franklin H., Sukhatme, Vikas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Biological and medical sciences Diseases of mother, fetus and pregnancy edema Female Gynecology. Andrology. Obstetrics HELLP syndrome HELLP Syndrome - etiology Humans Hypertension - etiology Kidney - pathology Medical sciences Nephrology. Urinary tract diseases Placenta - physiology PlGF Pre-Eclampsia - complications Pre-Eclampsia - etiology Pregnancy Pregnancy. Fetus. Placenta proteinuria Proteinuria - etiology pseudovasculogenesis Risk Factors soluble Flt-1 soluble VEGFR-1 Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Vascular Endothelial Growth Factor A - physiology VEGF
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Zusammenfassung:	Preeclampsia: A renal perspective. Preeclampsia is a syndrome that affects 5% of all pregnancies, producing substantial maternal and perinatal morbidity and mortality. The aim of this review is to summarize our current understanding of the pathogenesis of preeclampsia with special emphasis on the recent discovery that circulating anti-angiogenic proteins of placental origin may play an important role in the pathogenesis of proteinuria and hypertension of preeclampsia.
ISSN:	0085-2538 1523-1755
DOI:	10.1111/j.1523-1755.2005.00316.x