Vasorelaxant activity of phthalazinones and related compounds

The vasorelaxant activity of some dihydrostilbenamides, imidazo[2,1-a]isoindoles, pyrimido[2,1-a]isoindoles and phthalazinones has been evaluated. Three phthalazinones reverted the 10μM phenylephrine induced contraction with EC50

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2006-05, Vol.16 (10), p.2786-2790
Hauptverfasser:	Olmo, Esther del, Barboza, Bianca, Ybarra, Ma Inés, López-Pérez, José Luis, Carrón, Rosalía, Sevilla, Ma Angeles, Boselli, Cinthia, Feliciano, Arturo San
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiovascular system Dihydrostilbenamide Male Medical sciences Pharmacology. Drug treatments Phthalazines - chemistry Phthalazines - pharmacology Phthalazinone Rat aorta rings Rats Rats, Wistar Receptors, Adrenergic, alpha - classification Receptors, Adrenergic, alpha - drug effects Vas Deferens - drug effects Vas Deferens - physiology Vasodilation - drug effects Vasodilator agents. Cerebral vasodilators Vasorelaxant activity α1A, α1B and α1D sub-receptors affinity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The vasorelaxant activity of some dihydrostilbenamides, imidazo[2,1-a]isoindoles, pyrimido[2,1-a]isoindoles and phthalazinones has been evaluated. Three phthalazinones reverted the 10μM phenylephrine induced contraction with EC50
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.02.003