Cytochrome P4501A1 polymorphisms in the Amerindian and Mestizo populations of Mexico

Cytochrome P4501A1 polymorphisms in the Amerindian and Mestizo populations of Mexico

Several polymorphisms in the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We studied two CYP1A1 polymorphic sites (position 4889 and 6235) in a group of 212 unrelated healthy individuals belonging to three different Mexican...

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Veröffentlicht in:Cell biochemistry and function 2005-05, Vol.23 (3), p.189-193
Hauptverfasser: Fragoso, José Manuel, Juárez-Cedillo, Teresa, Hernández-Pacheco, Guadalupe, Ramírez, Erick, Zuñiga, Joaquín, Izaguirre, Raul, de la Peña, Aurora, Granados, Julio, Vargas-Alarcón, Gilberto
Format: Artikel
Sprache:eng
Schlagworte:
Amerindians
Cytochrome P-450 CYP1A1 - genetics
cytochrome P450
Gene Frequency
Genetic Predisposition to Disease
Genetics, Population
Genotype
Humans
Indians, North American - genetics
Language
Mexican populations
Mexico
Neoplasms - ethnology
Neoplasms - genetics
polymerase chain reaction
polymorphism
Polymorphism, Genetic
susceptibility
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Zusammenfassung:Several polymorphisms in the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We studied two CYP1A1 polymorphic sites (position 4889 and 6235) in a group of 212 unrelated healthy individuals belonging to three different Mexican populations (106 Mexican Mestizos, 52 Teenek and 54 Mayos). Comparison among Mexican populations showed increased frequency of the *Ile allele (A on position 4889) in Mexican Mestizos when compared to Amerindians (p 
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.1174