Structure-based design of protein tyrosine phosphatase-1B inhibitors

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template. Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been i...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-05, Vol.15 (10), p.2503-2507
Hauptverfasser:	Black, Emma, Breed, Jason, Breeze, Alexander L., Embrey, Kevin, Garcia, Robert, Gero, Thomas W., Godfrey, Linda, Kenny, Peter W., Morley, Andrew D., Minshull, Claire A., Pannifer, Andrew D., Read, Jon, Rees, Amanda, Russell, Daniel J., Toader, Dorin, Tucker, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Crystallography, X-Ray Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General and cellular metabolism. Vitamins Ligands Magnetic Resonance Spectroscopy Medical sciences Molecular Conformation Pharmacology. Drug treatments Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein tyrosine phosphatase-1B Protein Tyrosine Phosphatases - antagonists & inhibitors Structure-Activity Relationship Structure-based design Thiadiazines - chemistry Thiadiazines - pharmacology
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Zusammenfassung:	Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template. Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.03.068