Sylviside, a Diterpene Glucoside Derivative from Gnaphalium sylvaticum

A new diterpene glucoside (1), named sylviside, was isolated from the aerial parts of Gnaphalium sylvaticum. Its structure was elucidated as 2β,15α,20α-trihydroxy-19,20-dicarboxy-ent-kaur-16-ene 2β-O-(2‘-angelate)-β-d-glucopyranoside, on the basis of spectroscopic analysis (1H NMR, 13C NMR, HMQC, HM...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-03, Vol.69 (3), p.394-396
Hauptverfasser:	Konopleva, Mira M, Matławska, Irena, Wojcińska, Małgorzata, Ahmed, Rybczyńska, Maria, Paszel, Anna, Ohta, Shinji, Hirata, Toshifumi, Bylka, Wiesława, Mabry, Tom J, Cannon, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Asteraceae Biological and medical sciences chemical structure Crystallography, X-Ray cultured cells cytotoxicity Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoids Drug Resistance, Multiple Drug Screening Assays, Antitumor General pharmacology Genes, MDR - drug effects glucosides Glucosides - chemistry Glucosides - isolation & purification Glucosides - pharmacology Gnaphalium Gnaphalium - chemistry Gnaphalium sylvaticum HeLa Cells Humans Medical sciences medicinal plants Molecular Conformation Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals plant extracts Plants, Medicinal - chemistry Republic of Belarus spectral analysis stereochemistry sylviside
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A new diterpene glucoside (1), named sylviside, was isolated from the aerial parts of Gnaphalium sylvaticum. Its structure was elucidated as 2β,15α,20α-trihydroxy-19,20-dicarboxy-ent-kaur-16-ene 2β-O-(2‘-angelate)-β-d-glucopyranoside, on the basis of spectroscopic analysis (1H NMR, 13C NMR, HMQC, HMBC, NOESY), and was confirmed by X-ray crystallographic analysis. Sylviside (1) displayed weak cytotoxicity against HeLa WT (human epitheloid cervical carcinoma) cells and was also evaluated for its effects on reversing multidrug resistance in HeLa cells overexpressing MDR1.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np050144x