Stem Cells and Cancer: Two Faces of Eve

Stem Cells and Cancer: Two Faces of Eve

Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may...

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Veröffentlicht in:Cell 2006-03, Vol.124 (6), p.1111-1115
Hauptverfasser: Clarke, Michael F., Fuller, Margaret
Format: Artikel
Sprache:eng
Schlagworte:
Cell Differentiation
Cell Proliferation
Humans
Neoplasm Metastasis - pathology
Neoplasms - etiology
Neoplasms - pathology
Neoplasms - prevention & control
Stem Cells
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Beschreibung
Zusammenfassung:Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mechanisms that lead to cancer and suggest better modes of treatment.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2006.03.011