Levetiracetam Concentrations in Serum and in Breast Milk at Birth and during Lactation

Purpose: To study the pharmacokinetics of levetiracetam (LEV) at birth, during lactation, and in the nursed infant. Methods: Eight consecutive breast‐feeding women with epilepsy treated with LEV twice daily and their infants were studied. Results: The mean umbilical cord serum/maternal serum ratio w...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2005-05, Vol.46 (5), p.775-777
Hauptverfasser:	Johannessen, Svein I., Helde, Grethe, Brodtkorb, Eylert
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - analysis Anticonvulsants - blood Anticonvulsants - pharmacokinetics Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Breast Feeding Drug concentration Drug toxicity and drugs side effects treatment Epilepsy Epilepsy - blood Epilepsy - drug therapy Female Fetal Blood - chemistry Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Infant, Newborn - blood Lactation Lactation - blood Lactation - metabolism Levetiracetam Maternal-Fetal Exchange Medical sciences Milk, Human - chemistry Milk, Human - metabolism Nervous system (semeiology, syndromes) Neurology Neuropharmacology Parturition - blood Parturition - metabolism Pharmacology. Drug treatments Piracetam - analogs & derivatives Piracetam - analysis Piracetam - blood Piracetam - pharmacokinetics Pregnancy Pregnancy Complications - blood Pregnancy Complications - drug therapy Pregnancy Complications - metabolism Toxicity: cardiovascular system
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Zusammenfassung:	Purpose: To study the pharmacokinetics of levetiracetam (LEV) at birth, during lactation, and in the nursed infant. Methods: Eight consecutive breast‐feeding women with epilepsy treated with LEV twice daily and their infants were studied. Results: The mean umbilical cord serum/maternal serum ratio was 1.14 (range, 0.97–1.45) (n = 4). The mean milk/maternal serum concentration ratio was 1.00 (range, 0.76–1.33) at 3 to 5 days after delivery (n = 7). At sampling 2 weeks to 10 months after delivery (n = 5), it was similar (range, 0.85–1.38). At 3 to 5 days after delivery, the infants had very low LEV serum concentrations (
ISSN:	0013-9580 1528-1167
DOI:	10.1111/j.1528-1167.2005.54804.x