Secondary prevention after cryptogenic cerebrovascular events in patients with patent foramen ovale

Background: Patients with patent foramen ovale and cryptogenic stroke are at risk of recurrence, but there are few data on strategies to prevent this. Methods: We studied 280 consecutive patients with cryptogenic cerebrovascular events and a patent foramen ovale examined by multiplane transesophageal echocardiography. Patients received platelet inhibitors ( n=66) or anticoagulation ( n=47) or underwent device closure ( n=167). During the mean follow-up of 2.6 years, we compared the frequency of recurrent events, death and severe treatment complications. Results: A total of 33 (12%) patients had a recurrent cerebrovascular event. The annual recurrence rates were 13% in patients treated with platelet inhibitors, 5.6% in those on oral anticoagulation, and 0.6% in those after device closure. Independent predictors of recurrent cerebrovascular events were a patent foramen ovale larger than 4 mm (hazard ratio 3.8, 95% CI 1.2–11.2; p=0.017) or previous strokes (hazard ratio 4.3, 95% CI 2.0–9.2; p