A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women

A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women

A common –1607 GG/G polymorphism of the matrix metalloproteinase-1 ( MMP1) gene promoter was investigated in a series of Caucasian women with polycystic ovary syndrome (PCOS) and controls, by direct sequencing. In this prospective case–control study, the odds for women with at least one mutant GG al...

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Veröffentlicht in:Fertility and sterility 2005-05, Vol.83 (5), p.1565-1567
Hauptverfasser: Walch, Katharina, Nagele, Friedrich, Zeillinger, Robert, Vytiska-Binstorfer, Elisabeth, Huber, Johannes C., Hefler, Lukas A.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Alleles
Biological and medical sciences
Case-Control Studies
Confidence Intervals
European Continental Ancestry Group - genetics
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Matrix Metalloproteinase 1 - genetics
Medical sciences
Non tumoral diseases
Odds Ratio
Polycystic Ovary Syndrome - genetics
Polymorphism, Genetic - genetics
Prospective Studies
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Beschreibung
Zusammenfassung:A common –1607 GG/G polymorphism of the matrix metalloproteinase-1 ( MMP1) gene promoter was investigated in a series of Caucasian women with polycystic ovary syndrome (PCOS) and controls, by direct sequencing. In this prospective case–control study, the odds for women with at least one mutant GG allele of the MMP1 promoter to be diagnosed with PCOS was 2.7.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2004.11.043