Asymmetric Hydrogenation of Quinolines and Isoquinolines Activated by Chloroformates

Asymmetric Hydrogenation of Quinolines and Isoquinolines Activated by Chloroformates

Active ingredient: Optically active tetrahydroquinolines and tetrahydroisoquinolines can be obtained by the asymmetric hydrogenation of quinolines and isoquinolines with chloroformates as the activating reagent (e.g., ClCO2Bn, see scheme). The method has been applied to the asymmetric synthesis of s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2006-03, Vol.45 (14), p.2260-2263
Hauptverfasser: Lu, Sheng-Mei, Wang, You-Qing, Han, Xiu-Wen, Zhou, Yong-Gui
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric synthesis
chloroformates
enantioselectivity
hydrogenation
quinolines
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Active ingredient: Optically active tetrahydroquinolines and tetrahydroisoquinolines can be obtained by the asymmetric hydrogenation of quinolines and isoquinolines with chloroformates as the activating reagent (e.g., ClCO2Bn, see scheme). The method has been applied to the asymmetric synthesis of several naturally occurring alkaloids. Bn=benzyl.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200503073