Nonlinear Effects in Rh-Catalyzed Asymmetric Olefin Hydrogenation Using Mixtures of Chiral Monodentate P Ligands

Nonlinear Effects in Rh-Catalyzed Asymmetric Olefin Hydrogenation Using Mixtures of Chiral Monodentate P Ligands

Well mixed: A 1:1 mixture of two different binaphthol‐derived monophosphonite ligands (L) is employed in the Rh‐catalyzed hydrogenation of prochiral olefins (see scheme; cod=cyclooctadiene). Variation of the enantiopurity of the ligands results in unusual nonlinear effects; furthermore, >92 % ee...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-02, Vol.45 (9), p.1412-1415
Hauptverfasser: Reetz, Manfred T., Fu, Yu, Meiswinkel, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
hydrogenation
kinetics
nonlinear effects
rhodium
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Zusammenfassung:Well mixed: A 1:1 mixture of two different binaphthol‐derived monophosphonite ligands (L) is employed in the Rh‐catalyzed hydrogenation of prochiral olefins (see scheme; cod=cyclooctadiene). Variation of the enantiopurity of the ligands results in unusual nonlinear effects; furthermore, >92 % ee can be achieved even if one component is racemic.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200503604