The impact of donor spontaneous intracranial haemorrhage vs. other donors on long-term renal graft and patient survival

:  Background:  Donor cause of death has a significant impact on transplant survival in heart transplants recipients. The objective of this study was to determine if long‐term renal allograft and patient survival differed between grafts donated by donors who died of spontaneous intracranial haemorrh...

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Veröffentlicht in:Clinical transplantation 2006-01, Vol.20 (1), p.91-95
Hauptverfasser: Johnston, Olwyn, O'Kelly, Patrick, Spencer, Susan, Cunningham, Phyllis, Dorman, Anthony, Donohoe, John, Walshe, Joseph J, Hickey, David, Little, Dilly M, Conlon, Peter J
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Sprache:eng
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Zusammenfassung::  Background:  Donor cause of death has a significant impact on transplant survival in heart transplants recipients. The objective of this study was to determine if long‐term renal allograft and patient survival differed between grafts donated by donors who died of spontaneous intracranial haemorrhage (SIH) compared with those with other causes of death (OCOD). Methods:  Between 1990 and 2001, 1526 renal transplants were performed (711 SIH donors and 815 OCOD donors) at our unit. Serum creatinine levels at 1 yr, graft half‐life and annual graft failure rate were measured for both groups. Renal graft and patient survivals between the groups were compared. Relative risk for SIH donors and other confounding variables was measured using Cox proportional hazards models. Results:  Graft half‐life results were obtained for SIH (8 yr) and OCOD (10.13 yr) recipients. Graft and patient survival at 5 and 10 yr was 68.5% and 39.3% respectively for the SIH group vs. 76.8% and 51.9% respectively for the OCOD group (p 
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2005.00446.x