Increased xanthine oxidase activity after traumatic brain injury in rats

Oxidative stress may contribute to many of the pathophysiologic changes that occur after traumatic brain injury (TBI). There are a number of potential sources and mechanisms for oxygen free radical (OFR) production and lipid peroxidation after TBI. In this study, we investigate the time-dependent ch...

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Veröffentlicht in:	Journal of clinical neuroscience 2005-04, Vol.12 (3), p.273-275
Hauptverfasser:	Solaroglu, Ihsan, Okutan, Ozerk, Kaptanoglu, Erkan, Beskonakli, Etem, Kilinc, Kamer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - enzymology Brain Injuries - enzymology Brain Injuries - pathology brain injury Cytoplasm - enzymology Free Radicals - metabolism lipid peroxidation Lipid Peroxidation - drug effects Male Nitric Oxide Synthase - metabolism oxygen free radical Rats Rats, Sprague-Dawley Thiobarbituric Acid Reactive Substances - metabolism xanthine oxidase Xanthine Oxidase - metabolism
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Zusammenfassung:	Oxidative stress may contribute to many of the pathophysiologic changes that occur after traumatic brain injury (TBI). There are a number of potential sources and mechanisms for oxygen free radical (OFR) production and lipid peroxidation after TBI. In this study, we investigate the time-dependent changes in xanthine oxidase (XO) activity and lipid peroxidation using a focal TBI animal model. We demonstrate that there is an immediate increase in lipid peroxidation by-products and in XO enzyme activity after TBI.
ISSN:	0967-5868 1532-2653
DOI:	10.1016/j.jocn.2004.12.002