Concise Asymmetric Total Synthesis of Obolactone

Concise Asymmetric Total Synthesis of Obolactone

The first efficient asymmetric synthesis of obolactone 1 has been accomplished in 11 steps and with a 15% overall yield in which Brown's enantioselective allylation reactions and ring-closing metathesis reaction are key steps.

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Veröffentlicht in:Journal of organic chemistry 2006-03, Vol.71 (7), p.2918-2921
Hauptverfasser: Zhang, Jiyong, Li, Yang, Wang, Wenkuan, She, Xuegong, Pan, Xinfu
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - chemistry
Butanones - chemistry
Chemistry
Exact sciences and technology
Lactones - chemical synthesis
Lactones - chemistry
Magnolia - chemistry
Molecular Structure
Organic chemistry
Stereoisomerism
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Beschreibung
Zusammenfassung:The first efficient asymmetric synthesis of obolactone 1 has been accomplished in 11 steps and with a 15% overall yield in which Brown's enantioselective allylation reactions and ring-closing metathesis reaction are key steps.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo060028e