The impact of overweight on the development of diabetes after heart transplantation

: Background: Overweight is defined with a body mass index (BMI) >25. A BMI >25 is known as an independent risk factor for increased morbidity and mortality. The influence of an increased BMI on the development of diabetes and on survival after heart transplantation (HTX) was investigated. Methods: A total of 137 patients (116 men, 21 women), who underwent HTX at our Department from 1986 to 2002, were included in the study. For group stratification, the pre‐operative BMI values were taken (group I: BMI ≤25; group II: BMI > 25). Groups were compared for primary disease, age and sex, development of renal failure, development of diabetes, and survival. The probability of survival and the freedom‐from‐diabetes interval were calculated by the use of Kaplan–Meier method. Results: No significant differences between groups I and II were found concerning primary disease, age and sex, and occurrence of renal failure. There was a tendency towards increased survival (p = 0.18) in group I. Patients of group II developed diabetes after HTX more frequently than those of group I (p 25 is a highly significant independent risk factor for post‐operative development of diabetes mellitus (DM) (p