Design of an IV Formulation of an Unstable Prodrug Candidate for Prostate Cancer Treatment: Solution Chemistry of N-(glutaryl-hyp-ala-ser-cyclohexylglycyl-gln-ser-leu)-doxorubicin

ABSTRACT The chemical degradation of N-(glutaryl-hyp-ala-ser-cyclohexylglycyl-gln-ser-leu)-doxorubicin (henceforth referred to as doxorubicin peptide conjugate 1) was studied in buffered aqueous solution. The pH-rate profile of degradation shows that the doxorubicin conjugate is most stable between...

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Veröffentlicht in:	Drug development and industrial pharmacy 2006-01, Vol.32 (3), p.327-334
Hauptverfasser:	Karki, Shyam B., Treemaneekarn, Varaporn, Ostovic, Drazen, Nerurkar, Maneesh, Almarsson, Örn
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - therapeutic use Biological and medical sciences Calorimetry, Differential Scanning Chemistry, Pharmaceutical Degradation Doxorubicin - analogs & derivatives Doxorubicin - chemistry Doxorubicin - therapeutic use Doxorubicin peptide conjugate Drug Stability General pharmacology Humans Hydrogen-Ion Concentration Injections, Intravenous IV formulation Kinetics Lyophilization Male Medical sciences Oligopeptides - chemistry Oligopeptides - therapeutic use Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Preformulation Prodrug Prodrugs - chemistry Prostate cancer Prostatic Neoplasms - drug therapy Stability
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