On the mechanism of solubilization of drugs in the presence of poorly soluble additives

On the mechanism of solubilization of drugs in the presence of poorly soluble additives

A model is proposed which describes the solubilization of a poorly soluble drug in the presence of an insoluble excipient which forms an easily soluble compound with the drug. For sulfathiazole–calcium carbonate system as an example, it is demonstrated using sulfathiazole single crystals and powdere...

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Veröffentlicht in:International journal of pharmaceutics 2005-05, Vol.295 (1), p.177-182
Hauptverfasser: Boldyrev, V.V., Shakhtshneider, T.P., Chizhik, S.A.
Format: Artikel
Sprache:eng
Schlagworte:
Calcium carbonate
Calcium Carbonate - administration & dosage
Drug solubilization
Excipients
Insoluble excipient
Powders
Solubility
Sulfathiazole
Sulfathiazoles - chemistry
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Beschreibung
Zusammenfassung:A model is proposed which describes the solubilization of a poorly soluble drug in the presence of an insoluble excipient which forms an easily soluble compound with the drug. For sulfathiazole–calcium carbonate system as an example, it is demonstrated using sulfathiazole single crystals and powdered samples that the presence of insoluble additive causes an increase in dissolution rate and solubility of the drug.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2005.02.011