Covalent Hemin-DNA Adducts for Generating a Novel Class of Artificial Heme Enzymes

Covalent Hemin-DNA Adducts for Generating a Novel Class of Artificial Heme Enzymes

Well‐defined conjugates between DNA and heme enzymes are accessible by the reconstitution of apo‐enzymes with covalent hemin‐DNA adducts (see picture). This concept allows access to novel redox catalysts with programmable binding properties that may be applied as biocatalysts, sensors, and biomateri...

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Veröffentlicht in:Angewandte Chemie International Edition 2005-04, Vol.44 (17), p.2603-2606
Hauptverfasser: Fruk, Ljiljana, Niemeyer, Christof M.
Format: Artikel
Sprache:eng
Schlagworte:
DNA
DNA Adducts - chemistry
enzymes
Enzymes - chemistry
heme proteins
Hemin - chemistry
immobilization
self-assembly
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Beschreibung
Zusammenfassung:Well‐defined conjugates between DNA and heme enzymes are accessible by the reconstitution of apo‐enzymes with covalent hemin‐DNA adducts (see picture). This concept allows access to novel redox catalysts with programmable binding properties that may be applied as biocatalysts, sensors, and biomaterials.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200462567