Aortic wall thickness in newborns with intrauterine growth restriction

Aortic wall thickness in newborns with intrauterine growth restriction

Much epidemiological evidence has linked low birthweight with late cardiovascular risk. We measured aortic wall thickness (a marker of early atherosclerosis) by ultrasonography in 25 newborn babies with intrauterine growth restriction and 25 with normal birthweight. Maximum aortic thicknesses were s...

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Veröffentlicht in:The Lancet (British edition) 2005-04, Vol.365 (9469), p.1484-1486
Hauptverfasser: Skilton, Michael R, Evans, Nick, Griffiths, Kaye A, Harmer, Jason A, Celermajer, David S
Format: Artikel
Sprache:eng
Schlagworte:
Aorta, Abdominal - pathology
Arteriosclerosis - pathology
Babies
Birth Weight
Cardiovascular disease
Cardiovascular Diseases - pathology
Fetal Growth Retardation - pathology
Growth disorders
Health risks
Humans
Infant, Newborn
Neonates
Risk Factors
Tunica Intima - pathology
Tunica Media - pathology
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Zusammenfassung:Much epidemiological evidence has linked low birthweight with late cardiovascular risk. We measured aortic wall thickness (a marker of early atherosclerosis) by ultrasonography in 25 newborn babies with intrauterine growth restriction and 25 with normal birthweight. Maximum aortic thicknesses were significantly higher in the babies with intrauterine growth restriction (810 μm [SD 113]) than in those without (743 μm [76], p=0·02), more so after adjustment for birthweight (300 μm/kg [45] vs 199 μm/kg [29], p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(05)66419-7