Carboxamide-pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

Carboxamide-pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

The novel carboxamide-pyridine N-oxide synthon, sustained via N-H...O- hydrogen bonding and C-H...O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4'-bipyridine...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2006-01 (13), p.1369-1371
Hauptverfasser: Reddy, L Sreenivas, Babu, N Jagadeesh, Nangia, Ashwini
Format: Artikel
Sprache:eng
Schlagworte:
Amides - chemistry
Crystallization
Drug Design
Models, Molecular
Molecular Conformation
Pyridines - chemistry
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Zusammenfassung:The novel carboxamide-pyridine N-oxide synthon, sustained via N-H...O- hydrogen bonding and C-H...O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4'-bipyridine N,N'-dioxide.
ISSN:1359-7345
1364-548X
DOI:10.1039/b515510j