Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids

[Display omitted] Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids were synthesized in a two step procedure from the corresponding alkyl bis-dithiocarbamic salt intermediary. The novel compounds were evaluated for their activity in vitro against Trypanos...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2005-05, Vol.13 (10), p.3413-3421
Hauptverfasser:	Coro, Julieta, Pérez, Rolando, Rodríguez, Hortensia, Suárez, Margarita, Vega, Celeste, Rolón, Miriam, Montero, David, Nogal, Juan José, Gómez-Barrio, Alicia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antiparasitics Antitrichomonal Agents - chemical synthesis Antitrichomonal Agents - pharmacology Biological and medical sciences Carboxylic Acids - chemical synthesis Carboxylic Acids - pharmacology Cell Line Cell Survival - drug effects Chemotherapy Dose-Response Relationship, Drug Macrophages - drug effects Macrophages - metabolism Medical sciences Mice Pharmacology. Drug treatments Thiadiazine-2-thione Thiadiazines - chemical synthesis Thiadiazines - pharmacology Trichomonas vaginalis - drug effects Trypanosoma cruzi - drug effects
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Zusammenfassung:	[Display omitted] Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids were synthesized in a two step procedure from the corresponding alkyl bis-dithiocarbamic salt intermediary. The novel compounds were evaluated for their activity in vitro against Trypanosoma cruzi strain CL (clone CL B5) and Trichomonas vaginalis strain JH 31A.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/j.bmc.2005.03.009