Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level

Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP. We studied serum CRP in 3301 Framingham Heart Study (FHS) participants (mean age 61 years, 53...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2006-03, Vol.113 (11), p.1415-1423
Hauptverfasser:	KATHIRESAN, Sekar, LARSON, Martin G, DRAKE, Jared A, LEVY, Daniel, O'DONNELL, Christopher J, HIRSCHHORN, Joel N, BENJAMIN, Emelia J, VASAN, Ramachandran S, GUO, Chao-Yu, GONA, Philimon, KEANEY, John F, WILSON, Peter W. F, NEWTON-CHEH, Christopher, MUSONE, Stacy L, CAMARGO, Amy L
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Alleles Associated diseases and complications Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Pressure Body Mass Index C-Reactive Protein - analysis C-Reactive Protein - genetics Cardiology. Vascular system Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Cohort Studies Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Genetic Predisposition to Disease Genetic Variation Genotype Haplotypes - genetics Humans Lipids - blood Male Medical sciences Middle Aged Obesity - blood Polymorphism, Single Nucleotide Promoter Regions, Genetic Quantitative Trait, Heritable Sex Factors Smoking - epidemiology
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