Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level

Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level

Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP. We studied serum CRP in 3301 Framingham Heart Study (FHS) participants (mean age 61 years, 53...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 2006-03, Vol.113 (11), p.1415-1423
Hauptverfasser: KATHIRESAN, Sekar, LARSON, Martin G, DRAKE, Jared A, LEVY, Daniel, O'DONNELL, Christopher J, HIRSCHHORN, Joel N, BENJAMIN, Emelia J, VASAN, Ramachandran S, GUO, Chao-Yu, GONA, Philimon, KEANEY, John F, WILSON, Peter W. F, NEWTON-CHEH, Christopher, MUSONE, Stacy L, CAMARGO, Amy L
Format: Artikel
Sprache:eng
Schlagworte:
Age Factors
Aged
Alleles
Associated diseases and complications
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Body Mass Index
C-Reactive Protein - analysis
C-Reactive Protein - genetics
Cardiology. Vascular system
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - genetics
Cohort Studies
Diabetes. Impaired glucose tolerance
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Genetic Predisposition to Disease
Genetic Variation
Genotype
Haplotypes - genetics
Humans
Lipids - blood
Male
Medical sciences
Middle Aged
Obesity - blood
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Quantitative Trait, Heritable
Sex Factors
Smoking - epidemiology
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Zusammenfassung:Serum C-reactive protein (CRP) level is a heritable complex trait that predicts incident cardiovascular disease. We investigated the clinical and genetic sources of interindividual variability in serum CRP. We studied serum CRP in 3301 Framingham Heart Study (FHS) participants (mean age 61 years, 53% women). Twelve clinical covariates explained 26% of the variability in CRP level, with body mass index alone explaining 15% (P
ISSN:0009-7322
1524-4539
DOI:10.1161/circulationaha.105.591271