Predictors of health functioning in two high-risk groups of smokers

The relative and combined health effects of cigarette smoking, heroin use, and depression were examined in 322 clinically depressed smokers and 117 opioid-dependent smokers participating in two studies of the San Francisco Treatment Research Center. Opioid-dependent smokers averaged 16 years (S.D. = 9) of heroin use; 3% of depressed smokers used opiates in the past 6 months. Cigarettes per day ( M = 15, S.D. = 10) and Beck Depression (BDI-II) scores ( M = 21, S.D. = 11) were comparable between the two groups. Health functioning was assessed using the Medical Outcomes Study Short Form ( SF-36). Adjusting for demographic differences, depressed smokers reported better physical but poorer emotional health relative to opioid-dependent smokers. Both groups scored significantly lower than published norms ( p < .05). Within groups, severity of depressive symptoms, tobacco use, and opiate use were independent predictors of lower health functioning ( p < .05). Examining risk-related subgroups based on depression scores (BDI-II ≥ 20), cigarettes per day (≥1 pack), and opiate use, number of risk factors was monotonically related to health functioning in both samples. Individuals with two or more risk factors scored the lowest ( p < .05). Severity of depressive symptoms, tobacco use, and opiate use contributed individually and collectively to lower health functioning. Blended treatments that target multiple risk factors are needed to improve health outcomes.