Intercedensides D-I, cytotoxic triterpene glycosides from the sea cucumber Mensamaria intercedens Lampert

Six new triterpene glycosides, intercedensides D-I (1-6), were isolated from the whole bodies of the sea cucumber Mensamria intercedens Lampert, which is found in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis (NMR and ESIMS) and chemical methods. lntercede...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-04, Vol.68 (4), p.540-546
Hauptverfasser:	Zou, Z.G, Yi, Y.H, Wu, H.M, Yao, X.S, Du, L.J, Wu, J.H, Liaw, C.C, Lee, K.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticarcinogenic activity Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences cell lines chemical structure cytotoxicity Drug Screening Assays, Antitumor Echinodermata General pharmacology glycosides Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Holothurioidea Holothuroidea Humans intercedensides Marine Medical sciences Mensamaria intercedens Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Sea Cucumbers - chemistry spectral analysis Spectrometry, Mass, Electrospray Ionization Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoids Tumor Cells, Cultured
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Zusammenfassung:	Six new triterpene glycosides, intercedensides D-I (1-6), were isolated from the whole bodies of the sea cucumber Mensamria intercedens Lampert, which is found in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis (NMR and ESIMS) and chemical methods. lntercedensides D (1), E (2), G (4), and H (5) have a conjugated double bond system (22Z,24-diene) in the aglycon side chain, while intercedensides F (3) and I (6) have only a single double bond (24, 25) in this same chain. lntercedensides D-H (1-5) showed significant cytotoxicity (ED(50) 0.96-5.0 mug/mL) against 10 human tumor cell lines.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np040205b