Interferon-γ decreases replication of primary R5 HIV-1 isolates in thymocytes

As interferon-gamma (IFN-gamma) is produced at lower levels by neonatal than adult T cells, we determined whether IFN-gamma influences HIV-1 replication in thymocytes. IFN-gamma significantly decreased replication of R5 but not X4 viruses, and reduced depletion of CD3(hi)CD27 (mature) thymocytes, th...

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Veröffentlicht in:AIDS (London) 2006-04, Vol.20 (6), p.939-942
Hauptverfasser: PEDROZA-MARTINS, Livia, BOSCARDIN, W. John, ANISMAN-POSNER, Deborah J, REDSAR, Beverly N, BRYSON, Yvonne J, YANG, Otto O, UITTENBOGAART, Christel H
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Sprache:eng
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Zusammenfassung:As interferon-gamma (IFN-gamma) is produced at lower levels by neonatal than adult T cells, we determined whether IFN-gamma influences HIV-1 replication in thymocytes. IFN-gamma significantly decreased replication of R5 but not X4 viruses, and reduced depletion of CD3(hi)CD27 (mature) thymocytes, the preferential targets for R5 HIV-1. Thus infection and depletion of functionally mature thymocytes that can produce endogenous IFN-gamma may mutually contribute to HIV-1 replication in the thymus and to reduced T-cell output.
ISSN:0269-9370
1473-5571
DOI:10.1097/01.aids.0000218563.12897.ba