The T1128C Polymorphism of Neuropeptide Y Gene in a Chinese Population

Several papers have shown that the T1128C polymorphism of the neuropeptide Y (NPY) gene was related to certain diseases and disorders. However, the allele frequency of the 1128C showed significant differences among some populations with different genetic backgrounds, being absent in Japanese and Korean populations. Therefore, this present study was aimed to explore whether the T1128C polymorphism of the NPY gene exists in a Chinese population. A total of 304 newly diagnosed inpatients with coronary heart disease (CHD) were selected as the subjects in the present study. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis was performed to detect the T1128C polymorphism. Of the 304 CHD patients, only one patient showed the T1128/C1128 genotype in the NPY gene, the others were all the T1128/T1128 genotype. The T1128C polymorphism of the NPY gene is population specific and extremely low in a Chinese population.