Influence of early ICSI-derived embryo sHLA-G expression on pregnancy and implantation rates: a prospective study

Influence of early ICSI-derived embryo sHLA-G expression on pregnancy and implantation rates: a prospective study

BACKGROUND: We have previously reported the retrospective observation that when at least one embryo, transferred on day 3, expressed sHLA-G above the geometric mean (sHLA-G+) 46 h post-ICSI, there was a marked improvement in both pregnancy (PR) and implantation (IR) rates. METHODS: The media surroun...

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Veröffentlicht in:Human reproduction (Oxford) 2005-05, Vol.20 (5), p.1359-1363
Hauptverfasser: Sher, G., Keskintepe, L., Batzofin, J., Fisch, J., Acacio, B., Ahlering, P., Ginsburg, M.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Blastocyst - immunology
embryo
Embryo Implantation - physiology
Embryo Transfer
Female
Gene Expression Regulation, Developmental
Gynecology. Andrology. Obstetrics
Histocompatibility Antigens Class I - genetics
HLA Antigens - genetics
HLA-G Antigens
Humans
ICSI
implantation
Male
Maternal Age
Medical sciences
Pregnancy
Pregnancy Rate
Prospective Studies
sHLA-G
Sperm Injections, Intracytoplasmic
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Zusammenfassung:BACKGROUND: We have previously reported the retrospective observation that when at least one embryo, transferred on day 3, expressed sHLA-G above the geometric mean (sHLA-G+) 46 h post-ICSI, there was a marked improvement in both pregnancy (PR) and implantation (IR) rates. METHODS: The media surrounding individual embryos derived from ICSI performed on oocytes from 482 women ≤43 years of age were tested for sHLA-G expression by specific ELISA. RESULTS: We report here prospective results showing improved IVF results following the transfer of ‘good quality’ embryos (7–9 cells with
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/deh758