Cytokines, Skin, and Smallpox–A New Link to an Antimicrobial Peptide

Cytokines, Skin, and Smallpox–A New Link to an Antimicrobial Peptide

Patients with atopic dermatitis (AD) have an increased risk of infection with several viruses compared to patients with other inflammatory skin disorders such as psoriasis. In this issue of Immunity, Howell et al. (2006) find that the cytokine milieu in the skin of AD patients profoundly affects the...

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2006-03, Vol.24 (3), p.245-247
Hauptverfasser: Harrison, Jodie M., Ramshaw, Ian A.
Format: Artikel
Sprache:eng
Schlagworte:
Antimicrobial agents
Antimicrobial Cationic Peptides - biosynthesis
Cytokines
Cytokines - physiology
Dermatitis, Atopic - immunology
Humans
Immune system
Immunity, Innate
Infections
NF-kappa B - physiology
Skin - immunology
Skin - virology
Smallpox
Smallpox Vaccine - immunology
Studies
Vaccinia virus - immunology
Vaccinia virus - physiology
Virus Replication
Viruses
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Zusammenfassung:Patients with atopic dermatitis (AD) have an increased risk of infection with several viruses compared to patients with other inflammatory skin disorders such as psoriasis. In this issue of Immunity, Howell et al. (2006) find that the cytokine milieu in the skin of AD patients profoundly affects the innate response to vaccinia virus (VV) by blocking production of the antimicrobial peptide LL-37.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2006.03.003