Large-Scale Sequence Analysis of Avian Influenza Isolates

The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminar...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2006-03, Vol.311 (5767), p.1576-1580
Hauptverfasser:	Obenauer, John C, Denson, Jackie, Mehta, Perdeep K, Su, Xiaoping, Mukatira, Suraj, Finkelstein, David B, Xu, Xiequn, Wang, Jinhua, Ma, Jing, Fan, Yiping, Rakestraw, Karen M, Webster, Robert G, Hoffmann, Erich, Krauss, Scott, Zheng, Jie, Zhang, Ziwei, Naeve, Clayton W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Avian flu avian influenza Avian influenza virus Biological and medical sciences Birds - virology Computational Biology Epidemiology Fundamental and applied biological sciences. Psychology Genes Genes, Viral Genetics genome Genome, Viral Genomes Genomics Genotype & phenotype Genotypes Horses Human viral diseases Humans Infectious diseases Influenza A virus Influenza A virus - chemistry Influenza A virus - genetics Influenza A virus - isolation & purification Influenza A virus - pathogenicity Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H2N2 Subtype - genetics Influenza A Virus, H3N2 Subtype - genetics Influenza A Virus, H3N8 Subtype - genetics Influenza A Virus, H5N1 Subtype - chemistry Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - pathogenicity Influenza A Virus, H5N2 Subtype - genetics Influenza A Virus, H7N7 Subtype - genetics Influenza A Virus, H9N2 Subtype - genetics Influenza in Birds - virology Influenza, Human - virology isolation Medical sciences Microbiology Molecular Sequence Data Mutation Neurons nucleotide sequences Pandemics Phylogeny poultry Proteins Reassortant Viruses - genetics Research Article RNA, Viral - genetics Sequence Analysis, DNA Signatures strain differences strains Swine Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Proteins - chemistry Viral Proteins - genetics Virology Virulence Factors - chemistry Virulence Factors - genetics Viruses wild birds
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Zusammenfassung:	The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic. In spite of their substantial threat to human health, remarkably little AIV whole-genome information is available. We report here a preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes. We combine this new information with public AIV data to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1121586