Sequence variability of the human cytomegalovirus UL141 Open Reading Frame in clinical strains
Human cytomegalovirus (HCMV) displays genetic polymorphisms. HCMV disease and tissue tropism may be related to specific genomic variability among strains. This work analyzed the genetic polymorphism of UL141 open reading frame (ORF), one of the genes in HCMV UL/b' region, from 21 clinical strai...
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| Veröffentlicht in: | Archives of virology 2006-04, Vol.151 (4), p.827-835 |
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| creator | MA, Y.-P RUAN, Q HE, R QI, Y SUN, Z.-R JI, Y.-H HUANG, Y.-J LIU, Q CHEN, S.-R WANG, J.-D |
| description | Human cytomegalovirus (HCMV) displays genetic polymorphisms. HCMV disease and tissue tropism may be related to specific genomic variability among strains. This work analyzed the genetic polymorphism of UL141 open reading frame (ORF), one of the genes in HCMV UL/b' region, from 21 clinical strains. 8 previously published UL141 sequences in the GenBank were used for sequence comparison. Detailed sequence analysis showed that the UL141 gene was highly conserved at both the nucleotide and amino acid level. The coding regions were identical in size. The nucleotide and amino acid sequence identities among all strains were 96.9-100% and 97.6-100%, respectively. |
| doi_str_mv | 10.1007/s00705-005-0638-2 |
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HCMV disease and tissue tropism may be related to specific genomic variability among strains. This work analyzed the genetic polymorphism of UL141 open reading frame (ORF), one of the genes in HCMV UL/b' region, from 21 clinical strains. 8 previously published UL141 sequences in the GenBank were used for sequence comparison. Detailed sequence analysis showed that the UL141 gene was highly conserved at both the nucleotide and amino acid level. The coding regions were identical in size. The nucleotide and amino acid sequence identities among all strains were 96.9-100% and 97.6-100%, respectively.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-005-0638-2</identifier><identifier>PMID: 16195788</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Amino Acid Sequence ; Amino acids ; Biological and medical sciences ; Congenital diseases ; Cytomegalovirus ; Cytomegalovirus - genetics ; Cytomegalovirus Infections - virology ; Fetuses ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes, Viral ; Genomes ; Human cytomegalovirus ; Humans ; Infections ; Microbiology ; Microcephaly ; Miscellaneous ; Molecular Sequence Data ; Open Reading Frames - genetics ; Polymorphism, Genetic ; Reading ; Sequence Alignment ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Software ; Urine ; Viral infections ; Viral Proteins - genetics ; Virology</subject><ispartof>Archives of virology, 2006-04, Vol.151 (4), p.827-835</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag/Wien 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-ac56553549c12e311a72a0da53189d74e8a512ebeead62173f9af7aacd89264e3</citedby><cites>FETCH-LOGICAL-c387t-ac56553549c12e311a72a0da53189d74e8a512ebeead62173f9af7aacd89264e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17639893$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16195788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MA, Y.-P</creatorcontrib><creatorcontrib>RUAN, Q</creatorcontrib><creatorcontrib>HE, R</creatorcontrib><creatorcontrib>QI, Y</creatorcontrib><creatorcontrib>SUN, Z.-R</creatorcontrib><creatorcontrib>JI, Y.-H</creatorcontrib><creatorcontrib>HUANG, Y.-J</creatorcontrib><creatorcontrib>LIU, Q</creatorcontrib><creatorcontrib>CHEN, S.-R</creatorcontrib><creatorcontrib>WANG, J.-D</creatorcontrib><title>Sequence variability of the human cytomegalovirus UL141 Open Reading Frame in clinical strains</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><description>Human cytomegalovirus (HCMV) displays genetic polymorphisms. HCMV disease and tissue tropism may be related to specific genomic variability among strains. This work analyzed the genetic polymorphism of UL141 open reading frame (ORF), one of the genes in HCMV UL/b' region, from 21 clinical strains. 8 previously published UL141 sequences in the GenBank were used for sequence comparison. Detailed sequence analysis showed that the UL141 gene was highly conserved at both the nucleotide and amino acid level. The coding regions were identical in size. The nucleotide and amino acid sequence identities among all strains were 96.9-100% and 97.6-100%, respectively.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Biological and medical sciences</subject><subject>Congenital diseases</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - genetics</subject><subject>Cytomegalovirus Infections - virology</subject><subject>Fetuses</subject><subject>Fundamental and applied biological sciences. 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HCMV disease and tissue tropism may be related to specific genomic variability among strains. This work analyzed the genetic polymorphism of UL141 open reading frame (ORF), one of the genes in HCMV UL/b' region, from 21 clinical strains. 8 previously published UL141 sequences in the GenBank were used for sequence comparison. Detailed sequence analysis showed that the UL141 gene was highly conserved at both the nucleotide and amino acid level. The coding regions were identical in size. The nucleotide and amino acid sequence identities among all strains were 96.9-100% and 97.6-100%, respectively.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>16195788</pmid><doi>10.1007/s00705-005-0638-2</doi><tpages>9</tpages></addata></record> |
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| ispartof | Archives of virology, 2006-04, Vol.151 (4), p.827-835 |
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| subjects | Amino Acid Sequence Amino acids Biological and medical sciences Congenital diseases Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus Infections - virology Fetuses Fundamental and applied biological sciences. Psychology Genes Genes, Viral Genomes Human cytomegalovirus Humans Infections Microbiology Microcephaly Miscellaneous Molecular Sequence Data Open Reading Frames - genetics Polymorphism, Genetic Reading Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Software Urine Viral infections Viral Proteins - genetics Virology |
| title | Sequence variability of the human cytomegalovirus UL141 Open Reading Frame in clinical strains |
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