Sequence variability of the human cytomegalovirus UL141 Open Reading Frame in clinical strains

Human cytomegalovirus (HCMV) displays genetic polymorphisms. HCMV disease and tissue tropism may be related to specific genomic variability among strains. This work analyzed the genetic polymorphism of UL141 open reading frame (ORF), one of the genes in HCMV UL/b' region, from 21 clinical strai...

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Veröffentlicht in:	Archives of virology 2006-04, Vol.151 (4), p.827-835
Hauptverfasser:	MA, Y.-P, RUAN, Q, HE, R, QI, Y, SUN, Z.-R, JI, Y.-H, HUANG, Y.-J, LIU, Q, CHEN, S.-R, WANG, J.-D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Biological and medical sciences Congenital diseases Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus Infections - virology Fetuses Fundamental and applied biological sciences. Psychology Genes Genes, Viral Genomes Human cytomegalovirus Humans Infections Microbiology Microcephaly Miscellaneous Molecular Sequence Data Open Reading Frames - genetics Polymorphism, Genetic Reading Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Software Urine Viral infections Viral Proteins - genetics Virology
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Zusammenfassung:	Human cytomegalovirus (HCMV) displays genetic polymorphisms. HCMV disease and tissue tropism may be related to specific genomic variability among strains. This work analyzed the genetic polymorphism of UL141 open reading frame (ORF), one of the genes in HCMV UL/b' region, from 21 clinical strains. 8 previously published UL141 sequences in the GenBank were used for sequence comparison. Detailed sequence analysis showed that the UL141 gene was highly conserved at both the nucleotide and amino acid level. The coding regions were identical in size. The nucleotide and amino acid sequence identities among all strains were 96.9-100% and 97.6-100%, respectively.
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s00705-005-0638-2