Distinct Clinical Differences Between HLA-Cw0602 Positive and Negative Psoriasis Patients – An Analysis of 1019 HLA-C- and HLA-B-Typed Patients

Distinct Clinical Differences Between HLA-Cw0602 Positive and Negative Psoriasis Patients – An Analysis of 1019 HLA-C- and HLA-B-Typed Patients

A major susceptibility gene for psoriasis is located in the major histocompatibility complex class I region on chromosome 6 very close to the HLA-Cw6 gene. We collected a cohort of 1,019 patients with chronic plaque psoriasis. The patients were typed for HLA-C and HLA-B. A total of 654 (64.2%) were...

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Veröffentlicht in:Journal of investigative dermatology 2006-04, Vol.126 (4), p.740-745
Hauptverfasser: Gudjonsson, Johann E., Karason, Ari, Hjaltey Runarsdottir, E., Antonsdottir, Arna A., Hauksson, Valdimar B., Jónsson, Hjörtur H., Gulcher, Jeff, Stefansson, Kari, Valdimarsson, Helgi
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biological and medical sciences
Chromosomes, Human, Pair 6 - genetics
Chronic Disease
Dermatology
Female
HLA-B Antigens - analysis
HLA-C Antigens - analysis
HLA-C Antigens - genetics
Humans
Male
Medical sciences
Pregnancy
Psoriasis - diagnosis
Psoriasis - genetics
Psoriasis - immunology
Psoriasis. Parapsoriasis. Lichen
Severity of Illness Index
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Zusammenfassung:A major susceptibility gene for psoriasis is located in the major histocompatibility complex class I region on chromosome 6 very close to the HLA-Cw6 gene. We collected a cohort of 1,019 patients with chronic plaque psoriasis. The patients were typed for HLA-C and HLA-B. A total of 654 (64.2%) were HLA-Cw*0602 positive but 365 (35.8%) carried other HLA-C alleles. We confirmed that HLA-Cw*0602 positive patients have younger age of onset (17.5 vs 24.3 years, P
ISSN:0022-202X
1523-1747
DOI:10.1038/sj.jid.5700118