Association between the MLH1 gene and longevity

Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found...

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Veröffentlicht in:	Human genetics 2006-04, Vol.119 (3), p.353-354
Hauptverfasser:	DONG JO KIM, SANG MI YI, SEUNG YEON LEE, HEUN SOO KANG, CHOI, Yoon-Ho, YEONG WOOK SONG, SANG CHUL PARK
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Aged Aged, 80 and over Biological and medical sciences Carrier Proteins - genetics Classical genetics, quantitative genetics, hybrids Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Testing - methods Genetics of eukaryotes. Biological and molecular evolution Haplotypes Human Humans Longevity - genetics Male Middle Aged MutL Protein Homolog 1 Nuclear Proteins - genetics Polymorphism, Single Nucleotide
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Zusammenfassung:	Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/s00439-006-0148-7