Array Comparative Genomic Hybridization Identifies Genetic Subgroups in Grade 4 Human Astrocytoma
Alterations of DNA copy number are believed to be important indicators of tumor progression in human astrocytoma. We used an array of bacterial artificial chromosomes to map relative DNA copy number in 50 primary glioblastoma multiforme tumors at ∼1.4-Mb resolution. We identified 33 candidate sites...
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| Veröffentlicht in: | Clinical cancer research 2005-04, Vol.11 (8), p.2907-2918 |
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| container_title | Clinical cancer research |
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| creator | MISRA, Anjan PELLARIN, Malgorzata NIGRO, Janice SMIRNOV, Ivan MOORE, Dan LAMBORN, Kathleen R PINKEL, Daniel ALBERTSON, Donna G FEUERSTEIN, Burt G |
| description | Alterations of DNA copy number are believed to be important indicators of tumor progression in human astrocytoma. We used
an array of bacterial artificial chromosomes to map relative DNA copy number in 50 primary glioblastoma multiforme tumors
at ∼1.4-Mb resolution. We identified 33 candidate sites for amplification and homozygous deletion in these tumors. We identified
three major genetic subgroups within these glioblastoma multiforme tumors: tumors with chromosome 7 gain and chromosome 10
loss, tumors with only chromosome 10 loss in the absence of chromosome 7 gain, and tumors without copy number change in chromosomes
7 or 10. The significance of these genetic groups to therapeutics needs further study. |
| doi_str_mv | 10.1158/1078-0432.CCR-04-0708 |
| format | Article |
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an array of bacterial artificial chromosomes to map relative DNA copy number in 50 primary glioblastoma multiforme tumors
at ∼1.4-Mb resolution. We identified 33 candidate sites for amplification and homozygous deletion in these tumors. We identified
three major genetic subgroups within these glioblastoma multiforme tumors: tumors with chromosome 7 gain and chromosome 10
loss, tumors with only chromosome 10 loss in the absence of chromosome 7 gain, and tumors without copy number change in chromosomes
7 or 10. The significance of these genetic groups to therapeutics needs further study.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-04-0708</identifier><identifier>PMID: 15837741</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Brain tumor ; Cell Line, Tumor ; Chromosome Aberrations ; Cluster Analysis ; DNA array ; Genetic classification ; Glioblastoma - genetics ; Glioblastoma - pathology ; Glioblastoma Multiforme ; Glioma ; Humans ; In Situ Hybridization, Fluorescence ; Medical sciences ; Neurology ; Nucleic Acid Hybridization - methods ; Pharmacology. Drug treatments ; Reproducibility of Results ; Survival Analysis ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Clinical cancer research, 2005-04, Vol.11 (8), p.2907-2918</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-78b5cb86105f49a265529d584f8478141ef249f146144efe3b9343b815c2b5e53</citedby><cites>FETCH-LOGICAL-c401t-78b5cb86105f49a265529d584f8478141ef249f146144efe3b9343b815c2b5e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3354,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16706958$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15837741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MISRA, Anjan</creatorcontrib><creatorcontrib>PELLARIN, Malgorzata</creatorcontrib><creatorcontrib>NIGRO, Janice</creatorcontrib><creatorcontrib>SMIRNOV, Ivan</creatorcontrib><creatorcontrib>MOORE, Dan</creatorcontrib><creatorcontrib>LAMBORN, Kathleen R</creatorcontrib><creatorcontrib>PINKEL, Daniel</creatorcontrib><creatorcontrib>ALBERTSON, Donna G</creatorcontrib><creatorcontrib>FEUERSTEIN, Burt G</creatorcontrib><title>Array Comparative Genomic Hybridization Identifies Genetic Subgroups in Grade 4 Human Astrocytoma</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Alterations of DNA copy number are believed to be important indicators of tumor progression in human astrocytoma. We used
an array of bacterial artificial chromosomes to map relative DNA copy number in 50 primary glioblastoma multiforme tumors
at ∼1.4-Mb resolution. We identified 33 candidate sites for amplification and homozygous deletion in these tumors. We identified
three major genetic subgroups within these glioblastoma multiforme tumors: tumors with chromosome 7 gain and chromosome 10
loss, tumors with only chromosome 10 loss in the absence of chromosome 7 gain, and tumors without copy number change in chromosomes
7 or 10. The significance of these genetic groups to therapeutics needs further study.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain tumor</subject><subject>Cell Line, Tumor</subject><subject>Chromosome Aberrations</subject><subject>Cluster Analysis</subject><subject>DNA array</subject><subject>Genetic classification</subject><subject>Glioblastoma - genetics</subject><subject>Glioblastoma - pathology</subject><subject>Glioblastoma Multiforme</subject><subject>Glioma</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Nucleic Acid Hybridization - methods</subject><subject>Pharmacology. Drug treatments</subject><subject>Reproducibility of Results</subject><subject>Survival Analysis</subject><subject>Tumors of the nervous system. 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Drug treatments</topic><topic>Reproducibility of Results</topic><topic>Survival Analysis</topic><topic>Tumors of the nervous system. 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We used
an array of bacterial artificial chromosomes to map relative DNA copy number in 50 primary glioblastoma multiforme tumors
at ∼1.4-Mb resolution. We identified 33 candidate sites for amplification and homozygous deletion in these tumors. We identified
three major genetic subgroups within these glioblastoma multiforme tumors: tumors with chromosome 7 gain and chromosome 10
loss, tumors with only chromosome 10 loss in the absence of chromosome 7 gain, and tumors without copy number change in chromosomes
7 or 10. The significance of these genetic groups to therapeutics needs further study.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15837741</pmid><doi>10.1158/1078-0432.CCR-04-0708</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research; Alma/SFX Local Collection |
| subjects | Antineoplastic agents Biological and medical sciences Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumor Cell Line, Tumor Chromosome Aberrations Cluster Analysis DNA array Genetic classification Glioblastoma - genetics Glioblastoma - pathology Glioblastoma Multiforme Glioma Humans In Situ Hybridization, Fluorescence Medical sciences Neurology Nucleic Acid Hybridization - methods Pharmacology. Drug treatments Reproducibility of Results Survival Analysis Tumors of the nervous system. Phacomatoses |
| title | Array Comparative Genomic Hybridization Identifies Genetic Subgroups in Grade 4 Human Astrocytoma |
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