Array Comparative Genomic Hybridization Identifies Genetic Subgroups in Grade 4 Human Astrocytoma
Alterations of DNA copy number are believed to be important indicators of tumor progression in human astrocytoma. We used an array of bacterial artificial chromosomes to map relative DNA copy number in 50 primary glioblastoma multiforme tumors at ∼1.4-Mb resolution. We identified 33 candidate sites...
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Veröffentlicht in: | Clinical cancer research 2005-04, Vol.11 (8), p.2907-2918 |
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Sprache: | eng |
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Zusammenfassung: | Alterations of DNA copy number are believed to be important indicators of tumor progression in human astrocytoma. We used
an array of bacterial artificial chromosomes to map relative DNA copy number in 50 primary glioblastoma multiforme tumors
at ∼1.4-Mb resolution. We identified 33 candidate sites for amplification and homozygous deletion in these tumors. We identified
three major genetic subgroups within these glioblastoma multiforme tumors: tumors with chromosome 7 gain and chromosome 10
loss, tumors with only chromosome 10 loss in the absence of chromosome 7 gain, and tumors without copy number change in chromosomes
7 or 10. The significance of these genetic groups to therapeutics needs further study. |
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ISSN: | 1078-0432 1557-3265 |
DOI: | 10.1158/1078-0432.CCR-04-0708 |