Observations on the reactivity of thiyl radicals derived from 3,6-epidithiodiketopiperazine-2,5-diones and related congeners

A range of thiyl radicals derived from the reduced form of epidithiodiketopiperazines (ETPs) act as polarity reversal catalysts for the hydrosilylation of an enol lactone but not for H-atom abstraction from a model ribose ester. A range of thiyl radicals derived from the reduced form of epidithiodik...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2005-05, Vol.15 (9), p.2239-2242
Hauptverfasser:	Hilton, S.T., Motherwell, W.B., Potier, P., Pradet, C., Selwood, D.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry DNA cleavage Epidithiodiketopiperazines Exact sciences and technology Free Radicals Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Indicators and Reagents Kinetics Mechanism Models, Molecular Organic chemistry Piperazines - chemical synthesis Piperazines - chemistry Polarity reversal catalysis Preparations and properties Structure-Activity Relationship Sulfhydryl Compounds - chemistry Thiyl radicals
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Beschreibung
Zusammenfassung:	A range of thiyl radicals derived from the reduced form of epidithiodiketopiperazines (ETPs) act as polarity reversal catalysts for the hydrosilylation of an enol lactone but not for H-atom abstraction from a model ribose ester. A range of thiyl radicals derived from the reduced form of epidithiodiketopiperazines (ETPs) act as polarity reversal catalysts for the hydrosilylation of an enol lactone but not for H-atom abstraction from a model ribose ester.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2005.03.022