Adenoviral Gene Transfer of FGF-5 to Hibernating Myocardium Improves Function and Stimulates Myocytes to Hypertrophy and Reenter the Cell Cycle

Adenoviral Gene Transfer of FGF-5 to Hibernating Myocardium Improves Function and Stimulates Myocytes to Hypertrophy and Reenter the Cell Cycle

Fibroblast growth factors (FGFs) have diverse actions on the myocardium but the importance of stimulating angiogenesis versus direct effects of FGFs on cardiac myocytes is unclear. We used intracoronary injection of a replication-deficient adenoviral construct overexpressing FGF-5 (AdvFGF-5) to impr...

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Veröffentlicht in:Circulation research 2005-04, Vol.96 (7), p.767-775
Hauptverfasser: Suzuki, Gen, Lee, Te-Chung, Fallavollita, James A, Canty, John M
Format: Artikel
Sprache:eng
Schlagworte:
Adenoviridae - genetics
Animals
Apoptosis
Biological and medical sciences
Cardiomegaly - etiology
Cell Cycle
Cell Proliferation
Cell Size
Coronary Circulation
Fibroblast Growth Factor 5
Fibroblast Growth Factors - genetics
Fundamental and applied biological sciences. Psychology
Genetic Therapy
Ki-67 Antigen - analysis
Myocardial Stunning - pathology
Myocardial Stunning - physiopathology
Myocardial Stunning - therapy
Myocytes, Cardiac - pathology
Swine
Ventricular Function, Left
Vertebrates: cardiovascular system
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Zusammenfassung:Fibroblast growth factors (FGFs) have diverse actions on the myocardium but the importance of stimulating angiogenesis versus direct effects of FGFs on cardiac myocytes is unclear. We used intracoronary injection of a replication-deficient adenoviral construct overexpressing FGF-5 (AdvFGF-5) to improve flow and function in swine with hibernating myocardium. Two-weeks after AdvFGF-5 (n=8), wall-thickening increased from 2.4±0.04 to 4.7±0.7 mm in hibernating LAD regions (P
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.0000162099.01268.d1