Abnormal Eye Movements Predict Disability in MS: Two-Year Follow-Up

Abnormal Eye Movements Predict Disability in MS: Two-Year Follow-Up

: We conducted a two‐year follow‐up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17/40) remained significantly (p < .001) more disabled (median EDSS of 7.0) than those with normal eye movement...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2005-04, Vol.1039 (1), p.521-523
Hauptverfasser: DERWENSKUS, JOY, RUCKER, JANET C., SERRA, ALESSANDRO, STAHL, JOHN S., DOWNEY, DEBORAH L., ADAMS, NANCY L., LEIGH, R.JOHN
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Cerebellum
Circuits
Disabilities
Disabled Persons
Disease control
Eye movements
Female
Follow-Up Studies
Humans
internuclear ophthalmoplegia
Male
Middle Aged
Motors
Multiple Sclerosis - physiopathology
nystagmus
Nystagmus, Pathologic - etiology
Ocular Motility Disorders - etiology
Pathways
Patients
Pursuit, Smooth - physiology
saccadic dysmetria
Time Factors
Treatment Outcome
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Beschreibung
Zusammenfassung:: We conducted a two‐year follow‐up study of 40 patients with MS in whom we had reported that abnormal eye movements (AEM) were associated with greater general disability. AEM patients (17/40) remained significantly (p < .001) more disabled (median EDSS of 7.0) than those with normal eye movements (median EDSS of 5.0). AEM and great disability were associated with abnormal MRI signals in brainstem or cerebellum, where disease may involve control circuits for eye movements as well as descending motor pathways.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1325.058