Optical Probes for Biological Applications Based on Surface-Enhanced Raman Scattering from Indocyanine Green on Gold Nanoparticles

We report surface-enhanced Raman scattering (SERS) studies on indocyanine green (ICG) on colloidal silver and gold and demonstrate a novel optical probe for applications in living cells. In addition to its own detection by the characteristic ICG SERS signatures, the ICG gold nanoprobe delivers spati...

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Veröffentlicht in:	Analytical chemistry (Washington) 2005-04, Vol.77 (8), p.2381-2385
Hauptverfasser:	Kneipp, Janina, Kneipp, Harald, Rice, William L, Kneipp, Katrin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Applied sciences Biochemistry Carcinoma - pathology Cellular biology Exact sciences and technology Global environmental pollution Gold Colloid - pharmacokinetics Indocyanine Green - chemistry Male Metal Nanoparticles Nanoparticles Optics and Photonics - instrumentation Pollution Prostatic Neoplasms - pathology Rats Sensitivity and Specificity Silver Spectrum Analysis, Raman - instrumentation Spectrum Analysis, Raman - methods Surface Properties Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	We report surface-enhanced Raman scattering (SERS) studies on indocyanine green (ICG) on colloidal silver and gold and demonstrate a novel optical probe for applications in living cells. In addition to its own detection by the characteristic ICG SERS signatures, the ICG gold nanoprobe delivers spatially localized chemical information from its biological environment by employing SERS in the local optical fields of the gold nanoparticles. The probe offers the potential to increase the spectral specificity and selectivity of current chemical characterization approaches of living cells and biomaterials based on vibrational information.
ISSN:	0003-2700 1520-6882
DOI:	10.1021/ac050109v