New Allosteric Modulators of Metabotropic Glutamate Receptor 5 (mGluR5) Found by Ligand-Based Virtual Screening

Ligand‐based pharmacophore searching identified new allosteric modulators of metabotropic glutamate receptor 5 (mGluR5), a class III G protein‐coupled receptor. This virtual‐screening approach can be seen as a working alternative to more demanding structure‐based design techniques with the main aim...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2005-04, Vol.6 (4), p.620-625
Hauptverfasser:	Renner, Steffen, Noeske, Tobias, Parsons, Christopher G, Schneider, Petra, Weil, Tanja, Schneider, Gisbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site Animals Binding, Competitive - drug effects bioinformatics Cell Membrane - metabolism Databases, Factual drug discovery Drug Evaluation, Preclinical - methods Excitatory Amino Acid Antagonists - chemistry Excitatory Amino Acid Antagonists - metabolism Excitatory Amino Acid Antagonists - pharmacology G protein-coupled receptors Ligands Male Models, Molecular Molecular Conformation molecular modeling Molecular Structure Neural Networks (Computer) pharmacophore Prosencephalon - metabolism Pyridines - chemistry Pyridines - metabolism Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - metabolism Solubility
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Zusammenfassung:	Ligand‐based pharmacophore searching identified new allosteric modulators of metabotropic glutamate receptor 5 (mGluR5), a class III G protein‐coupled receptor. This virtual‐screening approach can be seen as a working alternative to more demanding structure‐based design techniques with the main aim of developing novel lead series.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.200400332