Palladium-Catalyzed Allylation of Alkynes with Allyl Alcohol in Aqueous Media: Highly Regio- and Stereoselective Synthesis of 1,4-Dienes

Palladium-Catalyzed Allylation of Alkynes with Allyl Alcohol in Aqueous Media: Highly Regio- and Stereoselective Synthesis of 1,4-Dienes

The direct approach: The unprecedented result of the title reaction (see scheme) is explained by a mechanism involving competition between π‐allylpalladation through cleavage of the CO bond and the insertion of an alkene. The procedure provides a highly stereo‐ and regioselective method to construc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2006-03, Vol.45 (12), p.1945-1949
Hauptverfasser: Huang, Jingmei, Zhou, Lei, Jiang, Huanfeng
Format: Artikel
Sprache:eng
Schlagworte:
alkynes
allylation
insertion
palladium
reaction mechanisms
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The direct approach: The unprecedented result of the title reaction (see scheme) is explained by a mechanism involving competition between π‐allylpalladation through cleavage of the CO bond and the insertion of an alkene. The procedure provides a highly stereo‐ and regioselective method to construct 1,4‐dienes in an economical and environmentally benign manner.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200503970