The Identification of 3,4-MDMA from Its Mass Equivalent Isomers and Isobaric Substances Using Fast LC-ESI-MS-MS
3,4-Methylenedioxymethamphetamine (3,4-MDMA, “Ecstacy”) and its 17 isomers and isobaric substances are studied using liquid chromatography (LC)-positive electrospray ionization-mass spectrometry (MS). 3,4-MDMA is a controlled substance, whereas in many countries the other studied isobaric compounds...
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Veröffentlicht in: | Journal of chromatographic science 2005-02, Vol.43 (2), p.92-97 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | 3,4-Methylenedioxymethamphetamine (3,4-MDMA, “Ecstacy”) and its 17 isomers and isobaric substances are studied using liquid chromatography (LC)-positive electrospray ionization-mass spectrometry (MS). 3,4-MDMA is a controlled substance, whereas in many countries the other studied isobaric compounds are not. A method for confirmation of the presence of 3,4-MDMA in drug seizures is developed and validated. Using single MS, the compounds produce an intense protonated molecule and some characteristic fragments; but tandem MS (MS-MS) is applied to enhance specificity. The MS-MS fragmentation is studied in order to distinguish 3,4-MDMA from the other 17 related compounds. However, the MS-MS spectra of 3,4-MDMA and six related compounds are very similar. Therefore, the LC-MS-MS method is developed for the unambiguous identification of 3,4-MDMA. The use of a monolithic column allows for 5-min gradient runs. This qualitative method is tested with 49 Ecstacy samples seized by the police. All results are congruent with the ones obtained with other methods. |
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ISSN: | 0021-9665 1945-239X |
DOI: | 10.1093/chromsci/43.2.92 |