Identification of an imipenem-resistant Pseudomonas aeruginosa clone among patients in a hospital in Rio de Janeiro

A total of 85 Pseudomonas aeruginosa isolates were obtained from October 1999 to April 2000 in a tertiary care hospital in Rio de Janeiro, Brazil. The imipenem susceptibility was evaluated by disk diffusion and agar dilution methods, and the clonal relationship among 67 isolates was examined by macr...

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Veröffentlicht in:	The Journal of hospital infection 2005-05, Vol.60 (1), p.19-26
Hauptverfasser:	Kokis, V.M., Moreira, B.M., Pellegrino, F.L.P.C., Silva, M.G., Long, J.B., Bastos, C.C.R., Santos, K.R.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Brazil - epidemiology Colony Count, Microbial Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - prevention & control Cross Infection - transmission DNA, Bacterial - analysis DNA, Bacterial - genetics Drug Resistance, Bacterial - genetics Electrophoresis, Gel, Pulsed-Field Genetic Variation - genetics Genotype Health Services Needs and Demand Hospitals, Military Hospitals, University Humans Imipenem Imipenem resistance Immunodiffusion Infection Control - methods Medical sciences Microbial Sensitivity Tests Molecular Epidemiology Molecular typing P. aeruginosa Pharmacology. Drug treatments Phylogeny Pseudomonas aeruginosa Pseudomonas aeruginosa - classification Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - epidemiology Pseudomonas Infections - microbiology Pseudomonas Infections - prevention & control Pseudomonas Infections - transmission Restriction Mapping Time Factors
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Zusammenfassung:	A total of 85 Pseudomonas aeruginosa isolates were obtained from October 1999 to April 2000 in a tertiary care hospital in Rio de Janeiro, Brazil. The imipenem susceptibility was evaluated by disk diffusion and agar dilution methods, and the clonal relationship among 67 isolates was examined by macrorestriction profile analysis following pulsed-field gel electrophoresis. Imipenem resistance was observed in 52 (61.2%) isolates. Imipenem-resistant P. aeruginosa isolates were separated into 10 genotypes, 73% of which belonged to genotype A. Identification of a single P. aeruginosa clone with a high rate of imipenem resistance emphasizes the need to control the transmission of this organism among patients.
ISSN:	0195-6701 1532-2939
DOI:	10.1016/j.jhin.2004.11.019