Therapeutic effects of clenbuterol in a murine model of amyotrophic lateral sclerosis

We investigated the effects of clenbuterol, a β2-adrenoceptor agonist with known anabolic and neuroprotective properties, on G93A-SOD1 mice, a transgenic murine model of familial amyotrophic lateral sclerosis (ALS). Relative to saline-treated vehicle controls (0.2 ml/kg/day; i.p.), early pathologic...

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Veröffentlicht in:Neuroscience letters 2006-04, Vol.397 (1), p.155-158
Hauptverfasser: Teng, Yang D., Choi, Howard, Huang, Wenzheng, Onario, Renna C., Frontera, Walter R., Snyder, Evan Y., Sabharwal, Sunil
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Sprache:eng
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Zusammenfassung:We investigated the effects of clenbuterol, a β2-adrenoceptor agonist with known anabolic and neuroprotective properties, on G93A-SOD1 mice, a transgenic murine model of familial amyotrophic lateral sclerosis (ALS). Relative to saline-treated vehicle controls (0.2 ml/kg/day; i.p.), early pathologic G93A-SOD1 mice treated with clenbuterol (1.5 mg/kg/day; i.p.) demonstrated a delayed onset of hindlimb signs as measured by rotarod performance, slowed disease progression, as well as trends toward mitigated losses of lumbar motoneurons and body weight. Responses in female G93A-SOD1 mice were favorable to those of males, suggesting synergistic effects between clenbuterol and sex-specific factors. Overall, our data suggest that clenbuterol offers therapeutic effects on ALS-related neuromuscular degeneration.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2005.12.007